循环肿瘤细胞（circulating tumor cell，ctc）发现已久，作为肿瘤转移和复发的关键因素，研究自发现以来从未止步。这些关键性的发现，让我们能够了解ctc，从而研发出相应的检测技术。作为（←戳链接看介绍）标志物的重要一类，ctc检测技术在肿瘤诊疗个体化的当下也愈发成熟。
本期我们追根溯源，
欢迎来到ctc的发现史！
#参考文献#
[1] epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells.
[2] mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development.
[3] isolation by size of epithelial tumor cells: a new method for the immunomorphological and molecular characterization of circulatingtumor cells.
[4] detection of circulating tumor cells in blood using an optimized density gradient centrifugation.
[5] role of organ selectivity in the determination of metastatic patterns of b16 melanoma.
[6] mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts.
[7] a positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.
[8] the distribution of secondary growths in cancer of the breast.
[9] a flattened mouse embryo: leveling the playing field.
[10] a case of cancer in which cells similar to those in the tumors were seen in the blood after death.
